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Di-Methyl-Tryptamine, commonly referred to as “DMT” is one of the most powerful psychoactive substances known to mankind, and interestingly is endogenously produced by the human body (along with many other forms of plant and animal life). This characteristic (biosynthesis by humans) is exceptional because it is not shared by any other psychedelic substance.
DMT is also the active hallucinogenic compound in ayahuasca, a tea brewed from the shrub Psychotria viridis used for ritual purposes by indigenous people in the Amazon. See our ayahuasca guide for more on this psychedelic brew.
People also ingest DMT in crystal form, smoking it in a pipe or bong, as well as vaporized. This form of ingestion produces a powerful but short-lasting hallucinogenic state, considered to be one of the most intense psychedelic experiences in existence.
However, while the body does naturally produce DMT (and perhaps produces it in much higher levels than previously thought), it also produces another compound called Monoamine Oxidase (MAO).
Monoamine oxidase effectively serves to nullify any psychoactive effects that perhaps would be felt due to the bodies naturally produced DMT, as it’s role in the body is to “clean” neuroreceptors by deaminating several different monoamine neurotransmitters (serotonin, dopamine, and norepinephrine are all monoamine neurotransmitters). N- N,Di-methyl-tryptamine is also a monoamine compound, so therefore is broken down by MAO before it has the chance to be transmitted through the brain from its point of synthesis in the cerebral cortex.
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